WebFigure 1 IRF1 binds to the promoter region of KPNA2 and negatively modulates KPNA2 transcription. (A) Diagram depicting the regions of predicted IRF1 binding sites (highlighted with blue and green boxes) within the KPNA2 promoter region (NC_000017.11, ranging from 68,035,602 to 68,046,859) based on two software packages, PROMO and TFBIND.The red … Web上海康朗生物科技有限公司主要致力于“Anti-phospho-c-Abl(Tyr272)抗体”的生产销售。多年的“Anti-phospho-c-Abl(Tyr272)抗体”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名称深受广大用户信赖。欢迎来电咨询或前来选购。 联系电 …
IRF1 interferon regulatory factor 1 - NIH Genetic Testing Registry …
WebThis maturation process was perturbed by specific inactivation of either NF-κB or IFN regulatory factor 1 (IRF1) in cDC1s, resulting in impaired expression of IFN-γ–responsive genes and consequently a failure to efficiently recruit and activate antitumoral CD8 + T cells. WebJul 9, 2015 · Irf1 constitutively expressed in the developing thymus plays an essential role in positive and negative selection of the CD8 + T cell repertoire [57,61]. MHC class I-restricted CD8 + T lymphocytes are directed against peptides derived from cytosolic proteins degraded by the proteasome that are translocated across the ER membrane by the TAP1 ... boonton coffee menu
IRF1 Promotes the Innate Immune Response to Viral …
WebJun 18, 2024 · Abstract. Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the immunobiology of cancer is emerging, IRF1-specific mechanisms ... WebJun 30, 2016 · We identified IRF1 as the STAT3-inducible proapoptotic factor mediating chemosensitization. Notably, our data show that pretreatment IRF1 expression correlates with the response to radio/chemotherapy in cervical cancer patients in vivo. Materials and Methods Immunohistochemical analysis Web002762 B6.129S2- Irf1 tm1Mak /J Type I interferon gene induction is abnormal in homozygous mice. They exhibit impairment of CD8 + T cell and NK cell maturation, … boonton coffee roasters