WebFeb 12, 2024 · In our study, we have discovered a transcription-independent function for STING in the restriction of viruses that contain RNA genomes. We found that cells lacking STING are sensitive to RNA virus infections and that during these infections, STING inhibits the translation machinery to prevent viral protein synthesis. WebFeb 20, 2024 · Cytosolic mRNA translation is subject to global and mRNA-specific controls. Phosphorylation of translation initiation factor eIF2 anchors a reversible switch that represses translation...
The Secret Life of Chloroplast Precursor Proteins in the Cytosol
WebJul 13, 2024 · Eukaryotic cells contain semi-autonomous organelles that have lost most of their coding capacity for essential proteins to the nucleus. Therefore, their functioning depends on the cytosolic translation products of nuclear-encoded genes that must be imported by a specialized protein import machinery. Chloroplasts import between 2500 … WebJan 26, 2024 · Moreover, solitary locusts slow cytosolic mRNA translation, leading to their longer lifespan than that of gregarious locusts. This phenomenon is consistent with the ability of cytosolic translation inhibition to extend lifespan in yeast, worms, flies, human cells, and mice by reducing the expression of RPs ( 30 ). iowa t-shirt shop
Mitochondrial Translation Efficiency Controls Cytoplasmic Protein ...
WebSynchronization of mitochondrial and cytoplasmic translation rates is critical for the maintenance of cellular fitness, with cancer cells being especially vulnerable to translational uncoupling. Although alterations of cytosolic protein synthesis are common in human cancer, compensating mechanisms in mitochondrial translation remain elusive. WebAug 9, 2024 · Ongoing cytosolic translation despite a repression of mitochondrial protein synthesis resulted in unbalanced translatomes, which lead to the upregulation of proteostasis genes. Results High-resolution profiling of human mitochondrial translation WebJan 26, 2024 · The isolation of translation-competent mitochondria through sequential centrifugation provides an alternative option to the compound-mediated shutoff of cytosolic translation for radiolabeling of the proteins synthesized in the organelle (24– 27).For example, this method can be applied for tissues that are difficult to pretreat with … iowatuckpointing.com