WebCCT369260: 2253878-44-1: 98.0%: 1; MuseChem provides custom synthesis service related to compound chemicals, especially peptide synthesis, and analytical service. Our services help you faster drug discovery and better bio-medical research. Share MuseChem . Service. Custom Synthesis. WebCCT369260 is a proteasome dependent monovalent BCL6 degrader with IC. 50 = 520 nM (TR-FRET). It is selective by proteomics vs 17 BTB/ZF domain proteins. Closest off …

S55746 hydrochloride (BCL201 hydrochloride) CAS 1448525-91-4 …

WebPotent, selective and cell-permeable inhibitors of protein function ("chemical probes") are valued reagents in both fundamental and applied biological research, and they are essential for the early stages of drug discovery by allowing preclinical target validation in both academic and industrial laboratories. Donated probe website KCGS website Webm.cnreagent.com 扫一扫，直接在手机上打开 the barn hairdressers stotfold

CCT369260 from MedChemExpress Biocompare.com

WebQuality Control Current batch: Purity >98% COA MSDS Product Information Biological Activity In vitro: A-1331852 selectively disrupts BCL-XL–BIM complexes and induces the hallmarks of apoptosis in BCL-XL–dependent Molt-4 cells with IC50s in the low nanomolar range but does not affect MEF cells lacking BAK or BAX. WebS-6 replacement using PHASER3 with a publicly available BCL6 structure4 (PDB code 3BIM) with ligand and water molecules removed used as molecular replacement model. The protein/ligand structure was manually corrected and rebuilt in COOT5 and refined with BUSTER6 in iterative cycles. Ligand restraints WebBCL6-IN-6 is a potent inhibitor of transcriptional repressor B-cell lymphoma 6 ( BCL6 ). BCL6-IN-6 significantly blocks the interaction of BCL6 with its corepressors and reactivates BCL6 target genes in a dose-dependent manner. BCL6-IN-6 has the potential for the research of diffuse large B-cell lymphoma (DLBCL). the barn half moon bay ca